Research Study Abstract

Relationship between Physical Activity and Plasma Fibrinogen Concentrations in Adults without Chronic Diseases

  • Published on Feb. 3, 2014

Objective: To analyze the relationship between regular physical activity, as assessed by accelerometer and 7-day physical activity recall (PAR), and plasma fibrinogen concentrations.

Methods: A cross-sectional study in a previously established cohort of healthy subjects was performed. This study analyzed 1284 subjects who were included in the EVIDENT study (mean age 55.0±13.6 years; 60.90% women). Fibrinogen concentrations were measured in blood plasma. Physical activity was assessed with a 7-day PAR (metabolic equivalents (METs)/hour/week) and GT3X ActiGraph accelerometer (counts/minute) for 7 days.

Results: Physical exercise, which was evaluated with both an accelerometer (Median: 237.28 counts/minute) and 7-day PAR (Median: 8 METs/hour/week). Physical activity was negatively correlated with plasma fibrinogen concentrations, which was evaluated by counts/min (r = −0.100; p<0.001) and METs/hour/week (r = −0.162; p<0.001). In a multiple linear regression analysis, fibrinogen concentrations of the subjects who performed more physical activity (third tertile of count/minute and METs/hour/week) respect to subjects who performed less (first tertile), maintained statistical significance after adjustments for age and others confounders (β = −0.03; p = 0.046 and β = −0.06; p<0.001, respectively).

Conclusions: Physical activity, as assessed by accelerometer and 7-day PAR, was negatively associated with plasma fibrinogen concentrations. This relation is maintained in subjects who performed more exercise even after adjusting for age and other confounders.

Figures: See full abstract for figures


  • Manuel A. Gomez-Marcos 1, 2
  • José I. Recio-Rodríguez 1
  • Maria C. Patino-Alonso 1, 3
  • Vicente Martinez-Vizcaino 4
  • Carme Martin-Borras 5
  • Aventina de-la-Cal-dela-Fuente 6
  • Ines Sauras-Llera 7
  • Alvaro Sanchez-Perez 8
  • Cristina Agudo-Conde 1
  • Luis García-Ortiz 1, 2
  • on behalf of the EVIDENT Study Investigators


  • 1

    Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service–SACYL, Salamanca, Spain

  • 2

    Department of Medicine, University of Salamanca, Salamanca, Spain

  • 3

    Stadistics Department, University of Salamanca, Salamanca, Spain

  • 4

    Social and Health Care Research Center, University of Castilla-La Mancha, Cuenca, Spain

  • 5

    DEA, Ciències de l'Educació i l'Esport (FPCEE) Universitat Ramon Llull, Barcelona, Spain

  • 6

    Casa of Barco Health Center, Castilla and León Health Service–SACYL,Valladolid, Spain

  • 7

    Torre Ramona Health Center, Aragón Health Service – Salud, Zaragoza, Spain

  • 8

    Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain




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